Niferin SR Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Side Effects Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Nifedipine

Indications/Uses

Chronic stable angina pectoris; HTN.

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Dosage/Direction for Use

Adult 30 or 60 mg once daily, may be increased to 120 mg once daily.

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Overdosage

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Administration

May be taken with or without food: Swallow whole, do not chew/break tab.

Contraindications

Hypersensitivity. Not to be used in cases of CV shock. Combination w/ rifampicin.

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Special Precautions

Not to be used in patients w/ Kock pouch. Patients w/ severe hypotension (systolic pressure <90 mmHg), heart failure, severe aortic stenosis; preexisting severe GI narrowing. False +ve effects w/ barium contrast X-ray. May affect ability to drive or operate machines. Hepatic impairment. May affect fertility in men. Not to be used during pregnancy & lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

Asthenia; vasodilatation, palpitation; constipation; edema, peripheral edema; dizziness, headache.

Drug Interactions

Potentiated BP-lowering effect w/ other antihypertensives. Severe hypotension w/ β-blockers. Altered clearance w/ CYP450 3A4 inhibitors or inducers. Increased plasma conc of digoxin, quinidine. Elevated plasma conc & potentiated anytihypertensive effect w/ cimetidine. Reduced bioavailability & weakened efficacy by rifampicin. Decreased clearance w/ diltiazem. Increased BP-lowering effect w/ grapefruit juice. Reduced bioavailability w/ phenytoin. Increased plasma conc w/ erythromycin. Increased systemic bioavailability w/ ketoconazole, itraconazole, fluconazole. Reduced dose w/ tacrolimus.

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Storage

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Description

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Action

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MIMS Class

Calcium Antagonists

ATC Classification

C08CA05 - nifedipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.

Regulatory Classification

Presentation/Packing

Form

Niferin SR tab 30 mg

Packing/Price

30's

Niferin SR

nifedipine

Manufacturer:

Abio

Distributor:

Apex